Which age group is at increased risk for systematic infections?

Individuals older than 50 years are at an increased risk for systemic infections due to several factors related to aging. As people age, their immune system typically becomes less effective at responding to infections. This immunosenescence results in a diminished response to both new and previously encountered pathogens, making older adults more susceptible to infections.

Additionally, older adults are more likely to have chronic health conditions such as diabetes, heart disease, and respiratory issues, which can further compromise their immune defenses. The presence of comorbidities can lead to a higher likelihood of hospitalization and complications from infections that younger populations might handle more effectively. The age-related decline in physiological functions and the increased incidence of polypharmacy also contribute to higher rates of inadvertent immune suppression, increasing the risk of systemic infections.

The other age groups listed typically have more robust immune systems that respond more effectively to infections, which lower their overall risk in comparison to those over 50.